EndoPlus Review (Replaced by SeroTrex)

Endoplus NeuroScience

EndoPlus (discontinued product) is a spray intended to maintain the normal levels of catecholamines and neurotransmitters in the brain. It is used to help people who experience rapid turnover of important neurotransmitters and therefore experience subsequent effects. EndoPlus claims to support serotonin production and modulate glutamate function. The proposed dose is 2 puffs of spray 3 to 4 times a day daily. EndoPlus spray was discontinued by its manufacturer and it was replaced by a new product in the form of dissolvable tablets called SeroTrex.

Manufacturer | Ingredients | Benefits | Reviews | Product Cost | Side Effects | Where To Buy? | More Supplements


NeuroScience is the manufacturing company of EndoPlus spray. This company is well known for the production and formulation of high-quality nutritional supplements for the endocrine system as well as for brain health. The company was set up in 1999 and is officially present in Wisconsin. It works to achieve its main goal i.e. normal and usual health of all the individuals globally. It operates in connection with Pharmasan Labs to make certain a good scientific research of their health products.

By their official websites and clients’ feedback, the NeuroScience looks promising company, which functions purely for the health benefits of the people.

For advice and additional information about this supplement or helpful tips, you can contact the manufacturing company directly at the following phone number: 1-888-342-7272.

EndoPlus Ingredients

EndoPlus consists of the amino acid theanine. This is an important amino acid and has been in use owing to its wonderful ability to grant a calming effect to the mind and stop over-stimulation. It also works to reduce the turnover of the epinephrine, norepinephrine, and other neurotransmitters as well as their urinary excretion.

EndoPlus also comprises 5-HTP which is known to enhance the levels of serotonin.  It is an important neurotransmitter which plays a role of neuromodulator to augment GABA function.

Other ingredients of this spray are Hydroxylated Lecithin, Stevia Rebaudiana leaf extract, Citric Acid, Potassium Sorbate, Purified Water and Natural Flavors. It is free of starch, artificial colors or flavors, salt, yeast or sucrose.


EndoPlus claims to enhance the levels of different types of feel-good neurotransmitters in the brain. It is specially designed for those people who have low levels due to the increased turnover of the neurotransmitters. Because of the presence of 5-HTP, it works to enhance serotonin levels. It’s another ingredient the theanine claims to stimulate and regulate the function of GABA. It is the main inhibitory neurotransmitter that works to stop over-stimulation. It affirms to enhance the function of GABA by stopping the activity of glutamate. Thus, EndoPlus states to increase the overall levels of the neurotransmitters. By doing so, it claims to treat different problems related to the low level of brain neurotransmitters.

Customer Reviews

We could not find any customer reviews for EndoPlus. This product is discontinued.

How Much Does EndoPlus Cost?

EndoPlus product was discontinued and replaced by SeroTrex.

Side Effects and Warnings

There is no known data regarding the side effects of EndoPlus. Even no such side effects have been reported by the people who use it. It is, therefore, suggested to use it after consulting with a doctor. If you experience any such adverse effects, it is necessary to stop its use and seek help from the doctor.

Endoplus should not be used concomitantly with monoamine oxidase inhibitors. The pregnant ladies and breastfeeding mothers should also avoid its use.

All the people who intend to use this spray should first consult their healthcare provider for complete information.

Where To Buy EndoPlus?

Unfortunately, EndoPlus product was discontinued by NeuroScience and it was replaced by SeroTrex. These supplements come in the form of tablets and can be ordered online from different places but our recommendation is to either buy it directly from the manufacturer or purchase it from trusted online retailers which may offer you discounts.

More Supplements From NeuroScience

We have researched other products from NeuroScience. Here is a complete list.

Review Sources

  1. Sero Trex Chewable Tablets. Published on https://www.neuroscienceinc.com/products/serotrex
  2. Neuro Science Sero Trex. Published on https://www.amazon.com/dp/B011SPUW4O/
  3. Hinz M, Stein A, Uncini T. 5-HTP efficacy and contraindications. Neuropsychiatr Dis Treat. 2012;8:323-8. doi: 10.2147/NDT.S33259. Epub 2012 Jul 19. PMID: 22888252; PMCID: PMC3415362.
  4. 5 Science-Based Benefits of 5-HTP, Written by Gavin Van De Walle, MS, RD on May 21, 2018, Published on https://www.healthline.com/nutrition/5-htp-benefits
  5. Weinberg-Wolf, H., Fagan, N.A., Anderson, G.M. et al. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacol 43, 1589–1598 (2018). https://doi.org/10.1038/s41386-017-0003-7
DHMReviews Supplements & Vitamins

Amna Sheikh is a medical doctor with a Bachelor of Medicine, Bachelor of Surgery (MBBS), Bachelors in Economics and Statistics.  She is also a medical writer working as a freelancer for 10+ years and she is specialized in medical, health, and pharmaceutical writing, regulatory writing & clinical research. All her work is supported by a strong academic and professional experience.

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